Your biggest opportunity probably lies under your own feet, in your current job, industry, education, experience or interests.
Brian Tracy

Replying to all resumes would be the polite thing to do, but often it simply isn't practical. If a company receives 200 responses for an ad, or experiences a continual deluge of unsolicited resumes, it would spend an inordinate amount of time sending acknowledgments. If you really want a receipt for your resume, send a stamped, self-addressed postcard asking for one. If you make it easy, the human resources department will comply.

Oh, you hate your job? Why didn't you say so? There's a support group for that. It's called EVERYBODY, and they meet at the bar.
Drew Carey