Tailor both the resume and cover letter. How many times have you heard people say they customize their cover letter, but send the same resume to everyone? Usually they are very proud of themselves for doing this, as many job seekers send one form letter and resume to everyone. Unfortunately, when a resume is competing with 200 to 400 others, it has to stand out from the crowd. Recruiters don't have time to separate the "diamonds from the dirt" in the 10 to 60 seconds they spend skimming for relevant experience. It is the candidate's responsibility to sort the valuable stuff from the extraneous, using only 20-carat material to land an interview.

My main job was developing talent. I was a gardener providing water and other nourishment to our top 750 people. Of course, I had to pull out some weeds, too.
Jack Welch

It used to be true that firms preferred to hire employed people because only the deadwood were let go from a company. However, in the past 10 years, corporate mergers and acquisitions, hostile takeovers, and right-sizings have put many highly qualif ied professionals on the street through no fault of their own. Prospective employers are aware of this trend. If you maintain your self-confidence and tell a potential employer what you can do for him, he will consider another firm's loss his gain.